Selection of the Carrier for Obtaining Dry Extractof Acorus calamus Leaves

Abstract

Abstract: Sweet flag (Acorus calamus L.) is a world-famous medicinal plant with valuable therapeutic properties. Numerous modern scientific researches described a wide range of therapeutic activity of the calamus and extracts from it, providing the expediency of the development of a drug based on this raw material. The main issue in our study was to determine a rational way to introduce Acorus calamus extract into a solid dosage form. First, literature analysis was carried out, which revealed that extracts in the dry state were the most technologically acceptable. Different methods of dry extract obtaining were theoretically studied from which the optimal one was chosen for experimental research. The optimal carrier was established through comparative studies of different excipients. According to indicators of finished product yield, drying time, hygroscopicity, and microscopic analysis it was found that the rationale was the combination of carriers Kollidon CL and Microcel 200. The experimental results based on the parameters of finished product yield, drying time, hygroscopicity, moisture absorption kinetics, flowability, bulk characteristics, as well as strength and disintegration time of the obtained tablets allowed us to conclude the best ratio of the components of the carrier for the extract of Acorus calamus leaves: Microcel 200 : Kollidon CL – 60 : 30.