The Lithuanian prospective study of patients with hidradenitis suppurativa based on clinical outcomes proposed by the European Reference Network for Rare and Complex Skin Disorders (ERN-Skin)

Abstract

Hidradenitis suppurativa (HS) is affecting 0.4- 4% of population. According to National Health Insurance fund‘s official information, the incidence of HS in Lithuania during 2006- 2015 was 23.5 cases per 100 000 population with female to male ratio 2:1. The average age of patients was 33 years. Only 7.7% of patients have been hospitalized, while outpatient management was used in 92.3% of cases. Till 2016, there were not used standardized outcome measures for HS activity and therapeutic effects. The demographic and clinical data of total 35 HS patients, included over 3 years period (2016- 2018) into local database of the referent centre of Rare Skin Diseases in Kauno klinikos, were analysed. Demographic results: of total, 51.4% were females. The mean age of patients was 38.6 years and the majority of them 68.6% (95% CI 52.02- 81.45) live in urban area. Median age was 39 years when the disease was diagnosed and median duration of the diagnosis delay was 4 years. One of three patients (31.4% (95% CI 18.55- 47.98)) had BMI≥30kg/m² – obesity, 14.3% (95% CI 6.26-29.38) of patients had BMI 25-29.9 kg/m2 - overweight. 20% (95%CI 8.1- 32.68) were of Hurley I stage, 45.7% (95% CI 30.46- 61.81) of Hurley II and 17.1% (95%CI 8.1- 32.68) of Hurley III stage. The median evaluation of PGA was 3 points and the average of DLQI was 10.9 before the treatment. Half of patients (48.6% (95% CI 32.99- 64.43)) had involvement of 3 or more body sites, 28.6% (95% CI 16.33- 45.05) and 22.9% (95% CI 12.07- 39.02) had involvement of 2 and 1 site, accordingly. Bacterial sample from abscesses/fistules was taken from 62.9% patients. Negative culture results were found in 72.7% of samples. Bacteriological analysis showed group- C beta- hemolytic streptococci (n = 1), S. aureus (n = 5), P. mirabilis (n = 1), P. aeruginosa (n = 1). Combined medical and surgery treatment was applied to 51.4% and mon[...].