Association of myocardial injury biomarkers and left ventricular functional parameters in STEMI patients treated with PPCI

Abstract

Introduction Acute myocardial infarction (MI) - is a condition characterized as extensive myocardial damage with active inflammatory response which leads to left ventricular (LV) remodeling and functional impairment [1]. Cardiac magnetic resonance imaging (CMR) is a gold standard method for assessing LV function, which is the key prognosticator in ST elevation myocardial infarction (STEMI) patients [2]. Additionally, CMR enables us to incorporate myocardial strain, which is more specific approach in detecting early or subclinical LV functional changes [3]. Combining this sensitive technique with biomarkers for myocardial necrosis and inflammation may allow us to detect high-risk STEMI patients and improve the prognosis of adverse cardiac events [4]. Aim To investigate the relationship between LV functional parameters from CMR and laboratory biomarkers in patients presenting with acute STEMI treated with primary percutaneous coronary intervention (PPCI) Methods The study included 30 patients with acute STEMI. Laboratory tests, such as troponin I, leukocytes, neutrophils, hs-CRP (high sensitivity - C reactive protein) and CRP were examined after PPCI. Baseline CMR was performed 2-5 days after ACS (n=30). Followup imaging was performed 6 months later (n=26). CMR analysis included the quantification of LV ejection fraction, as well as the measurement of global longitudinal (GLS) and global circumferential (GCS) strain using the eature tracking technique. These parameters were carried out using Medis 3.2 software. The differences between baseline and follow-up CMR parameters were compared, and the correlations between CMR results and laboratory findings were investigated. The statistical analysis was carried out using SPSS version 28.0.1.0.The result was declared statistically significant when the calculated p value was less than 0.05. […].