„Trimerazin Lux“ efektyvumo tyrimai gydant virškinimo trakto infekcinėmis ligomis sergančius veršelius ir paršelius

Abstract

Bakterinių ligų sukėlėjai kiaulių ir galvijų fermose yra įvairios enterobakterijos. Dažniausiai sutinkamos E. coli ir Salmonella enterica rūšių bakterijos, sukeliančios gyvuliams virškinamojo trakto infekcines ligas. Su virškinimo trakto infekcinėmis ligomis sergančiais paršeliais ir veršeliais atlikti preparato „Trimerazin Lux“ efektyvumo tyrimai. „Trimerazin Lux“ in vitro palyginti su neomicinu ir linkospektinu salmoneles (praskaidrėjusios zonos plotis 20,4±1,2 mm), ešerichijas (praskaidrėjusios zonos plotis 18,9±2,1 mm) ir enterobakterijas (praskaidrėjusios zonos plotis 22,5±1,4 mm) veikė daug geriau (p<0,05). Tyrimais nustatyta, kad „Trimerazin Lux“ poveikis gydant virškinimo trakto ligomis sergančius paršelius buvo 100%, o „Trimerazin Polfa“ – 96,6% . Gydant „Trimerazin Lux“ 30 kolibakterioze ir salmonelioze sergančių veršelių, pasveiko 29 (96,6%), o „Trimerazin Polfa“ – 18 (93,3%). „Trimerazin Lux“ toksiškumo požymių ir vaisto pašalinio poveikio nenustatyta. Gydant paršelius ir veršelius, sergančius infekcinėmis virškinimo trakto ligomis, preparatas buvo efektyvus ir netoksiškas. Clinical trials in swine and calves herds were performed using sulfamethoxazole and trimethoprim combination – “Trimerazinas Lux”. Before experiment pathogenic microorganisms (Salmonella enteritidis and E. coli K99) from calves were isolated and E. coli K88, Pseudomonas aeruginosa, Enterobacter cloacae and Proteus mirabilis were isolated from pigs. The control groups of pigs and calves equal in size were treated using commercial drug Trimerazin (Polfa, Poland). The results on antimicrobial effects revealed that “Trimerazin Lux" in vitro was most efficacious against Enterobacter cloacae (transparency zone – 22.5±1.4 mm), against Salm. choleraesuis (transparency zone – 20.4±1.2 mm), against Salm. choleraesuis (transparency zone – 20,4±1,2 mm), and against E.coli (transparency zone – 18.9±2.1 mm). Clinical trials showed that effectiveness of “Trimerazin Lux” in pigs was 100%, i.e. all pigs were recovered. Effeciency in control group was 96.6%, i.e. one pig in this group died. Preparations were also effective in treatment of salmonellosis and colibacillosis in calves. One calf from testing group (total 30 calves) died and two calves died in the control group. The effeciency of “Trimerazinas Lux” and “Trimerazin Polfa” was 96.6% and 93.3%, respectively. There were no statistical difference between groups. After treatment with “Trimerazinas Lux” no side effects were registered. According our results it was concluded that combination of sulphamethoxazole and trimethoprim – “Trimerazinas Lux” – is a safe and effective preparation for treatment of microorganisms diseases in pigs and calves.