Influence of diabetes mellitus type 2, thyrotropic hormone and chronic stress on insulin-1 growth factor and bone mineral metabolism

Abstract

Introduction People nowadays often experience episodic or long-term stress. Also the population of patients with diabetes mellitus and thyroid gland disorders is rising. In order to better understand the mechanism of bone reparation we made a hypothesis that chronic stress, diabetes and thyroxine metabolism disorders might have direct influence on bone reparation. Aim Research the effect of chronic stress and thyrotropic hormone on IGF-1 and bone mineral metabolism in diabetes mellitus type 2 patients. Objectives 1. Determine the level of chronic stress in diabetes mellitus type 2 cases. 2. Measure the amounts of IGF-1, Ca, P and TTH in blood of diabetes mellitus type2 patients. 3. Determine the level of chronic stress in healthy patients (control group). 4. Analyse the effect of diabetes and chronic stress on concentration of TTH, Ca, P and IGF-1 in blood. Methods 355 patients with diabetes mellitus type 2 were enrolled in this trial and 45 subjects were used as control group. To determine chronic stress both subject groups were surveyed using HAD scale and M.I.N.I. International Neuropsychiatric Interview by Dr. David Sheehan. All subjects were divided into four groups: healthy and undergoing chronic stress (HS), healthy for whom chronic stress was not determined (HN), diabetes mellitus type 2 patients and undergoing chronic stress (DMS), diabetes mellitus type 2 patients for whom chronic stress was not determined (DMN). Levels of Ca, P, IGF-1, TTH, glycated hemoglobin in venous blood were tested in all subjects. Data was processed using Statistical Package for the Social Sciences (SPSS) 13.0 software package. Results Female subjects experience stress and anxiety more frequently than male subjects. HS subject group shows lower levels of calcium in blood by 2,20-2,15 mmol/L and normal amounts of phosphorus. HN group shows normal amounts of both calcium and phosphorus in venous blood. DMN group shows normal amo[...].