Treatment of Hypoxic Ischemic Encephalopathy in Neonates to Improve Long-term Outcomes.
Ghirmatsion, Milen Dawit |
Recenzentas / Reviewer | |
Komisijos pirmininkas / Committee Chairman | |
Komisijos narys / Committee Member | |
Komisijos narys / Committee Member | |
Komisijos narys / Committee Member | |
Komisijos narys / Committee Member | |
Komisijos narys / Committee Member |
The aim of this article is to review the literature data on the possibilities of treatment of neonates born with asphyxia/hypoxia for the improvement of long-term outcomes.Objectives: 1)To revise and summarise the latest literature data on treatment tactics for term neonates with hypoxic-ischemic encephalopathy last 5-10 years,2)To establish the evidence supporting newest treatment for neonates with hypoxic-ischemic encephalopathy (HIE), and 3)Long term outcomes neonates with hypoxic-ischemic encephalopathy.Methodology: The article collection was done in line with the PRISMA methodology. The following key terms were used to search the PubMed and Google Scholar databases for studies: Hypoxic-ischaemic encephalopathy, neonatal, treatment, long-term outcomes The initial search yielded 10792 articles from the two databases. Additional filters (human studies, English language, and published between 2012 and 2021) were then applied, and the remaining papers were manually screened according to the eligibility criteria, yielding the 23 publications included in this review.Results: The 23 articles that were selected, consisted of both retrospective and prospective studies. All articles were clinical trials and the studies included evaluated the effectiveness of erythropoietin, melatonin, xenon, allopurinol, magnesium sulphate, and other neuroprotective treatments by analysing the short and long-term effects and outcomes. Conclusion and Practical Recommendations: Therapeutic hypothermia is the standard treatment of HIE in neonates which decreases the brain injury and has a neuroprotective effect until late childhood. New treatments such as erythropoietin, melatonin, and xenon were more effective when given in combination with TH rather than as the main treatment. Erythropoietin has shown great potential for neuromotor developmental outcomes at 18 months. There is a higher prevalence of neurophysiology, cognitive, and psychopathology sequelae found in patients treated for HIE that survived till adolescence. Therefore, long-term follow-up examinations are critical in childhood to detect early neurodevelopmental abnormalities and initiate therapeutic intervention.
Šiame tyrime buvo lyginami literatūros duomenys apie hipoksinės išeminės encefalopatijos gydymą naujagimiams bei vertinamas įvairių naujų gydymo metodų veiksmingumas ir saugumas ir jų ilgalaikes baigtis.